Andrea Scozzafava Selected Research

Carbonic Anhydrases (Carbonic Anhydrase)

1/2017	Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis.
1/2016	Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies.
1/2016	Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma.
1/2016	Synthesis and inhibition potency of novel ureido benzenesulfonamides incorporating GABA as tumor-associated carbonic anhydrase IX and XII inhibitors.
4/2015	A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.
12/2014	Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.
6/2014	Sulfonamides and their isosters as carbonic anhydrase inhibitors.
1/2014	Glaucoma and the applications of carbonic anhydrase inhibitors.
1/2014	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis.
9/2013	Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides.

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Andrea Scozzafava Research Topics

Disease

127	Neoplasms (Cancer) 12/2016 - 03/2002
27	Glaucoma 01/2017 - 02/2002
18	Hypoxia (Hypoxemia) 01/2015 - 06/2004
9	Alzheimer Disease (Alzheimer's Disease) 06/2015 - 01/2002
8	Breast Neoplasms (Breast Cancer) 03/2013 - 03/2005
6	Neoplasm Metastasis (Metastasis) 01/2016 - 01/2010
5	Rheumatoid Arthritis 01/2018 - 09/2003
5	Obesity 06/2014 - 02/2004
5	Carcinogenesis 07/2013 - 11/2005
4	Epilepsy (Aura) 01/2016 - 06/2007
4	Periodontitis 09/2014 - 07/2013
4	Infections 06/2014 - 07/2002
4	Weight Loss (Weight Reduction) 01/2013 - 03/2005
3	Chagas Disease (American Trypanosomiasis) 08/2013 - 02/2013
3	Prostatic Neoplasms (Prostate Cancer) 06/2013 - 03/2005
3	HIV Infections (HIV Infection) 01/2007 - 04/2002
2	Ocular Hypertension (Glaucoma, Suspect) 01/2017 - 06/2011
2	Neuralgia (Stump Neuralgia) 01/2016 - 04/2015
2	Pathologic Processes 03/2015 - 08/2006
2	Brain Neoplasms (Brain Tumor) 07/2013 - 01/2010
2	Chronic Disease (Chronic Diseases) 07/2013 - 01/2010
2	Carcinoma (Carcinomatosis) 06/2013 - 06/2011
2	Acidosis 05/2011 - 01/2008
2	Nervous System Diseases (Neurological Disorders) 09/2009 - 03/2003
2	Macular Degeneration (Age-Related Maculopathy) 01/2008 - 01/2007
2	Taste Disorders (Taste Disorder) 01/2008 - 01/2007
2	Renal Cell Carcinoma (Grawitz Tumor) 11/2004 - 06/2004
2	Disease Progression 02/2004 - 03/2003
1	Amnesia (Dissociative Amnesia) 01/2017

Drug/Important Bio-Agent (IBA)

90	Carbonic Anhydrases (Carbonic Anhydrase)IBA 01/2017 - 05/2003
74	Protein Isoforms (Isoforms)IBA 01/2016 - 08/2003
72	IsoenzymesIBA 09/2013 - 02/2002
68	SulfonamidesIBA 01/2016 - 03/2002
33	Carbonic Anhydrase InhibitorsIBA 01/2018 - 03/2003
33	EnzymesIBA 12/2016 - 05/2003
16	Carbonic Anhydrase IXIBA 01/2016 - 03/2003
14	ZincIBA 02/2012 - 05/2003
8	BenzenesulfonamidesIBA 01/2016 - 04/2005
8	Pharmaceutical PreparationsIBA 09/2015 - 09/2003
8	AnionsIBA 04/2015 - 10/2003
7	Acetazolamide (Diamox)FDA LinkGeneric 01/2017 - 03/2003
7	Proteins (Proteins, Gene)FDA Link 07/2013 - 06/2004
6	CoumarinsIBA 01/2017 - 12/2010
6	dorzolamide (Trusopt)FDA LinkGeneric 05/2015 - 03/2003
6	sulfamic acid (ammonium sulfamate)IBA 01/2014 - 12/2003
6	Sulfhydryl Compounds (Thiols)IBA 02/2013 - 05/2005
5	Bicarbonates (Hydrogen Carbonate)IBA 01/2010 - 06/2004
5	Protons (Proton)IBA 01/2010 - 06/2004
5	AminesIBA 10/2009 - 08/2007
4	Antineoplastic Agents (Antineoplastics)IBA 01/2016 - 01/2004
4	Oxygen (Dioxygen)IBA 01/2015 - 06/2004
4	Sulfanilamide FDA Link 12/2014 - 02/2004
4	Anticonvulsants (Antiepileptic Drugs)IBA 01/2013 - 03/2003
4	Carbon DioxideIBA 01/2010 - 06/2004
3	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2018 - 01/2004
3	Topiramate (Topamax)FDA LinkGeneric 01/2013 - 03/2005
3	coumarinIBA 01/2012 - 12/2010
3	Amino Acids FDA Link 04/2008 - 08/2007
3	Methazolamide FDA LinkGeneric 01/2008 - 03/2003
3	Ethoxzolamide (Ethamide)FDA Link 01/2008 - 03/2003
3	Matrix Metalloproteinases (MMPs)IBA 03/2007 - 09/2003
3	brinzolamide (Azopt)FDA Link 01/2004 - 03/2003
2	CalciumIBA 06/2015 - 02/2013
2	Fluorescein (Funduscein)FDA LinkGeneric 11/2014 - 06/2007
2	SaltsIBA 11/2014 - 04/2007
2	Anti-Bacterial Agents (Antibiotics)IBA 02/2014 - 03/2005
2	chetominIBA 07/2013 - 01/2010
2	Lactic Acid (Lactate)FDA LinkGeneric 06/2013 - 02/2005
2	Doxorubicin (Adriamycin)FDA LinkGeneric 03/2013 - 01/2012
2	Zonisamide (Zonegran)FDA LinkGeneric 01/2013 - 06/2007
2	Anti-Obesity Agents (Antiobesity Drugs)IBA 01/2013 - 08/2006
2	N- (3- chloro- 7- indolyl)- 1,4- benzenedisulphonamide (E7070)IBA 08/2012 - 01/2004
2	Antiglaucoma AgentsIBA 07/2012 - 08/2006
2	BoronIBA 05/2011 - 07/2005
2	CaspasesIBA 05/2011 - 09/2003
2	Biomarkers (Surrogate Marker)IBA 05/2011 - 06/2007
2	Indicators and Reagents (Reagents)IBA 01/2010 - 06/2004
2	Transcription Factors (Transcription Factor)IBA 01/2010 - 05/2008
2	Biological ProductsIBA 04/2009 - 02/2008
2	CopperIBA 11/2008 - 01/2008
2	DisulfidesIBA 09/2006 - 09/2006
2	NitratesIBA 01/2006 - 02/2005
2	SteroidsIBA 03/2005 - 05/2003
2	SulfatasesIBA 03/2005 - 05/2003
2	Growth InhibitorsIBA 06/2003 - 03/2002
1	Ketoprofen (Orudis)FDA LinkGeneric 01/2017
1	KetorolacIBA 01/2017
1	Diclofenac (SR 38)FDA LinkGeneric 01/2017
1	Sulindac (Copal)FDA LinkGeneric 01/2017
1	Cyclooxygenase InhibitorsIBA 01/2017
1	Carbonic Anhydrase IIIBA 01/2017
1	Indomethacin (Indometacin)FDA LinkGeneric 01/2017
1	Ibuprofen (Motrin)FDA LinkGeneric 01/2017
1	Phenylalanine (L-Phenylalanine)FDA Link 01/2017

Therapy/Procedure

32	Therapeutics 01/2015 - 01/2002
5	Radiotherapy 01/2015 - 07/2005
5	Drug Therapy (Chemotherapy) 01/2015 - 05/2003
2	Topical Administration 06/2013 - 05/2004
2	Boron Neutron Capture Therapy 05/2011 - 07/2005
2	Highly Active Antiretroviral Therapy (HAART) 01/2007 - 01/2005